A low complexity Per-Antenna Power Control (PAPC) approach based on Minimum Mean Squared Error (MMSE) detection for V-BLAST is proposed in this paper. The PAPC approach is developed for minimizing the Bit Error Rate (BER) averaged over all substreams when the data throughput and the total transmit power keep constant over time. Simulation results show that the Power-controlled V-BLAST (P-BLAST) outperforms the conventional V-BLAST in terms of BER performance with MMSE detector, especially in presence of high spatial correlation between antennas. However, the additional complexity for P-BLAST is not high. When MMSE detector is adopted, the P-BLAST can achieve a comparable BER performance to that of conventional V-BLAST with Maximum Likelihood (ML) detector but with low complexity.